Controlling biomolecular condensates via chemical reactions

Atom Mapping of Chemical of Chemical Reactions via Constraint Programming

A chemical reaction is a process of transforming one set of molecules (educts) into another set (products). In the course of a reaction, chemical bonds which hold the atoms together are redistributed, so that each atom in a reaction educt appears in a specific position of a reaction product. Tracing atoms between educts and products refers to a non-trivial problem in computational chemistry and...

Proportional-Integral Degradation (PI-Deg) control allows accurate tracking of biomolecular concentrations with fewer chemical reactions

We consider the design of synthetic embedded feedback circuits that can implement desired changes in the concentration of the output of a biomolecular process (reference tracking in control terminology). Such systems require the use of a “subtractor”, to generate an error signal that captures the difference between the current and desired value of the process output. Unfortunately, standard imp...

Chemical reactions.

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

Determination of disulfide bond connecting patterns via tandem mass spectrometry (MSn) and biomolecular ion/radical reactions

Durand, Kirt Lenroy. Ph.D., Purdue University, December 2014. Determination of Disulfide Bond Connecting Patterns via Tandem Mass Spectrometry (MS) and Biomolecular Ion/Radical Reactions. Major Professor: Yu Xia. Disulfide bond formation is one of the most common post translational modifications to occur in proteins and naturally occurring peptides. Disulfide bond formation plays a critical rol...